NOVEL ANTI-TUBERCULOSIS DRUGS
Introduction: Tuberculosis is a highly contagious disease, caused by Mycobacterium tuberculosis, which belongs to the genus MYCOBACTERIUM ( 3 ). It is an air-borne infection. Mycobacterium tuberculosis enters the host through nostrils and affects lungs, but can also affects the central nervous system, lymphatic system, and circulatory system ( 2 ). Tuberculosis is known as PHTHISIS or CONSUMPTION , which means the deadliest disease to human ( 4 ). Mycobacterium tuberculosis can cause two types of infections: 1. Active contagious tuberculosis 2. Latent tuberculosis Active contagious tuberculosis is diagnosed by chest X-rays, microscopic examination of sputum (Acid fast bacilli or AFB staining), and microbiological culture of sputum. Whereas latent tuberculosis (Mycobacterium tuberculosis present in the body remains inactive and symptoms do not appear) is diagnosed by Mantoux tuberculin skin test and interferon gamma release assays (IGRAs) of the blood ( 2 ). Tuber