Welcome to Sindh Biotechnologist Association

Introduction SARS-CoV-2 becomes a global challenge after it hits millions of deaths worldwide. Researchers from different parts of the world are doing vaccine trials against COVID-19. World Health Organization announced that the only way to reduce COVID-19 cases is by taking precautionary measures and maintaining social distances until an effective vaccine is produced. Many countries throughout the World also control the number of increasing cases by following these precautions. As scientists are trying to develop vaccines, they are also doing research on the structure, function and pathway of coronavirus when it attacks the host cells with the help of proteomics and multi-omics studies. Coronavirus and Proteomics In 2019, novel coronavirus was emerged as a pandemic flu from Wuhan city, China and spread throughout the world. The main source of transmission of SARS-CoV-2 is contact with the infected patient via sneezing and coughing because of his/her respiratory droplets contains...

INTRODUCTION SARS-CoV-2 is the pathogen responsible for COVID-19. This disease got emerged from Wuhan city in China and has been declared as the global emergency situation by WHO (of the International, 2020) . This pandemic affected the economy of the world badly with about 2,101,164 confirmed cases. STRUCTURE OF VIRUS AND ITS ENTRY IN CELL It is a single-stranded RNA enveloped virus comprising of 4 proteins namely Spike, Envelope, Nucleo-capsid and Membrane proteins. Spike proteins cover its outer surface and are involved in attachment to the host cell receptor. SARS-CoV-2 gains entry into the cell through ACE-2 receptors (Walls et al., 2020) . When these spike proteins bind to the receptors, Transmembrane serine proteases get active and mediates viral entry into the host cell and after entrance viral RNA is released into the host cell (Wang et al., 2020) and then replication and transcription of the viral genome take place. The synthesis, assemblage and packaging of viral prot...