Welcome to Sindh Biotechnologist Association

This lecture is presented by our volunteer Sajid Ali Shah, he is from Islamabad, Pakistan, and he is covering "Dengue Virus: Genomic Insights, Pathogenic Mechanisms, and Therapeutic Approaches". for Video:  for slides: Dengue Virus: Genomic Insights, Pathogenic Mechanisms, and Therapeutic Approaches from SindhBiotech

1. Introduction Hantaviruses are the rodent borne viruses that cause severe clinical illness in human. Each strain of hantavirus is specific to a particular rodent host and cause and different clinical disease [1]. It belongs to the family of Bunyaviridae. The virus was recognized as a pathogenic virus in the previous decades. First case of hantavirus was diagnosed in 1993, during an endemic in Southwestern U.S. In human, it usually cause two types of disease including Hantavirus pulmonary syndrome (HPS) and Hantavirus hemorrhagic fever with renal syndrome (HFRS) [2]. Nephropathia epidemica (NE) is another disease caused by hantavirus, mostly seen in Europe. 2. Structure of Hantavirus Hantaviruses are the enveloped viruses having three negative sense single-stranded RNA segments designated as small (S), medium (M) and large (L) as shown in Figure 1. S segment is involved in the coding of Nucleocapsid protein (NP) while M and L segments are coding for the surface envelope glycoprote...