β-Thalassemia Awareness In General Population
INTRODUCTION Pakistan's population is predicted to be 225,633,392 (225 million). In Pakistan, the β-thalassemia (β-thal) trait frequency is between 5.0 and 7.0%, implying that there are more than 10 million carriers; and each year, approximately 5000 children are diagnosed with β-thal major (β-TM) in Pakistan. Thalassemias are a diverse set of hereditary illnesses caused by a reduction in the production of the alpha or beta chains of haemoglobin (Hb). Haemoglobin is the component of red blood cells that transports oxygen. It is made up of two proteins, an alpha and a beta. If the body does not produce enough of one or both of these proteins, red blood cells do not form correctly and cannot carry enough oxygen, resulting in anaemia that begins in childhood and lasts throughout life. Thalassemia is an inherited condition, which means that at least one of the parents must be a carrier. β-thalassemia is hereditary haemoglobin (Hb) production disorder characterised by poor Hb synt...