"Uncovering the Intricate Role of Autophagy in Skin Health: From Cellular Homeostasis to Disease Pathogenesis"
Autophagy is a highly conserved process that involves the creation of autophagosomes, which ultimately fuse with lysosomes, enabling the breakdown of misfolded proteins and damaged organelles through the action of their enzymatic components. The fundamental role of autophagy lies in maintaining cellular homeostasis, both in normal physiological conditions and in pathological states. Moreover, it has been well-established that dysfunctions in autophagy contribute to the pathophysiology of various human diseases, underlining its critical significance in cellular health and disease processes [1, 2 ]. In the early 1960s, while studying lysosomes, Christian de Duve discovered autophagy, the process involving the formation of vesicles that engulf and digest cellular components, leading to the term "autophagy" or "self-eating." Autophagy plays a vital role in maintaining skin health and is particularly important in the context of skin diseases. It helps remove damaged...